What Is IGF-1 LR3?

IGF-1 LR3, also known as Long-R3-IGF-1, is a synthetic form of insulin-like growth factor-1. Its structure has been modified by adding 13 amino acids and substituting one, making it more potent and significantly longer-lasting in the body. While natural IGF-1 typically breaks down within about 12 hours, IGF-1 LR3 can remain active for approximately 20–30 hours. This extended duration is one reason it has gained attention in performance and recovery settings, as well as in aesthetic applications.

Why Is It Relevant in Aesthetic Medicine?

The prolonged activity of IGF-1 LR3 makes it a potential option for treatments focused on improving muscle tone, supporting tissue repair, enhancing skin quality, and promoting metabolic balance. It falls under the broader category of IGF-1 peptide therapy, which is becoming increasingly popular in anti-aging and performance-based care.

However, it is important to clarify that IGF-1 LR3 is not FDA-approved, and its use outside of research or certain wellness clinics is considered experimental.