what is stenabolic sr9009?

stenabolic sr9009?

SR9009 (Stenabolic) is a synthetic compound that functions as a REV-ERB agonist, enhancing the repression of genes controlled by the REV-ERBα and REV-ERBβ receptors (IC50 values of approximately 670 nM and 800 nM, respectively).

By activating REV-ERB receptors, SR9009 has been shown in animal studies to reduce circadian locomotor activity during the dark cycle and modify the expression of core clock genes in the hypothalamus of mice. Additionally, exposure to SR9009 altered the circadian regulation of various metabolic genes in the liver, skeletal muscle, and adipose tissue, which was associated with increased energy expenditure.

In studies involving diet-induced obese mice, administration of SR9009 (100 mg/kg, intraperitoneally, twice daily for 30 days) resulted in reduced fat mass and significant improvements in lipid profiles and blood glucose levels.

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